대한대장항문학회

Purpose : The ulcerative colitis is a major chronic intestinal disease of unknown etiology<br>affecting principally the rectum and left colon, and its incidence is markedly increasing in<br>Korea. The main differential diagnosis of ulcerative colitis is an acute self-limited colitis. This<br>study was performed to evaluate difference of cell kinetics between chronic ulcerative colitis<br>and acute self-limited colitis. Methods : The normal colon (n=25), acute self-limited colitis<br>(n=25) and chronic ulcerative colitis (n=25) were investigated by using Ki-67<br>immunohistochemical staining for proliferation and TUNEL method for apoptosis. The Ki-67<br>labeling indices and TUNEL labeling indices were determined. Results : The means of Ki-67<br>labeling indices in normal colon, acute self-limited colitis and chronic ulcerative colitis were<br>5.14 5.25%, 6.81 5.73%, 13.10 10.15%, respectively. And the means of TUNEL labeling<br>indices in normal colon, acute self-limited colitis and chronic ulcerative colitis were 1.59<br>0.10%, 2.54 1.60%, 2.51 1.40%, respectively. Conclusions : The apoptosis is one of method<br>of cell loss in both acute self-limited colitis and chronic ulcerative colitis. High proliferative<br>activity of chronic ulcerative colitis may predispose to mutational events in colonic mucosa,<br>therefore may be one of the increased cancer risk factors in chronic ulcerative colitis.<br>