대한대장항문학회

The usefulness of serical CEA(carcinoembryonic antigen) determinations in s1aging,<br>detection, prognosis monitoring of therapy in patients with colorectal cancer has been<br>reported frequently during past the 20 years.<br>CEA in now the most widely used and to most useful marker for many cancers,<br>including those of the clown, lung, pancreas, and breast.<br>In this study, in order to clarify the mechanism by which CEA is released into<br>peripheral blood, bile through the liver and rectal secretion, 20 patients with cotorectal<br>cancer were examined for the correlation between CEA levels in peripheral and inferior<br>mesenteric vein(IMV) blood, and gallbladder bile, and rectal secretion. They were also<br>examined for the change of CEA levels in IMV blood during operation immediately after<br>laparotomy and after resection of the cancer lesions. 20 patients of benign anal disease<br>(hemorroid, anal fistula and fissure) were included in this study as control group.<br>The results were as follows:<br>1) The mean CEA level of peripheral blood in colorectal cancer patients<br>was<br>significantly higher than that of Peripheral blood in benign anal disease Patients. In<br>colorectal cancer group; 2.9 ± 1.52 ng/ml, In benign anal disease group: 0.9=0.51 ng/<br>ml(P≤ 0.0001).<br>2) The mean CEA level in IMV blood during operation was significantly higher than<br>that of peipheral blood in colorectal(cancer) patients. In IMV blood: 5.3 = 4.5 ng/ml, In<br>peripheral blood; 2.9± 1.92 ng/ml(p≤ 0.05).<br>3) The mean CEA level in IMV 1기cod immediately after laparotomy(5.3±4.54 ng/ml)<br>was not significantly different from that in IMV blood after the resection of cancer<br>lesions(5.6±5.18 ng/ml)<br>4) Gallbladder bile CEA levels were observed in 4 patients with hepatic metastasis<br>from the colorectal cancer. In 2 patients;>80ng/ml, In one patient; 12.0 ng/ml and the<br>other one patient; 5.6 ng/ml.<br>5) The CEA levels in rectal secretion of the Patients with benign and malignant<br>disease were high as > 80ng/ml.<br>