³í¹® »ó¼¼ º¸±â
(PDF file / 6 pages)
View
| Down
Title
Clinical Trial of Oxaliplatin, 5-Fluorocuracil, and Leucovorin in Advanced Colorectal Cancer: 48 Cases
Author
Seung Hyun Lee, Byung Kwon Ahn, Sung Uhn Baek
Place of duty
Publicationinfo
Journal of Korean Soc Coloproctol 2002 | Vol.18 No.6 | 402 ~ 407, 6 pages
Keyword
´ëÀåÁ÷Àå¾Ï; Ç×¾ÏÈÇпä¹ý; ¿Á»ì¸®Çöóƾ; Colorectal cancer; Chemotherapy; Oxaliplatin;
Abstract
Purpose:
Although 5-fluorouracil (5-FU) has been used as the basis of chemotherapy regimen for colorectal cancer for more than 40 years, 5-FU as single agent treatment has rarely achieved objective response rates higher than 15% in
advanced
colorectal cancers. The modulation of 5-FU with biologic modifiers has resulted in higher response rates, but survival advantages was not meaningful. Oxaliplatin is one of the newly developed drugs with proven activity against colorectal cancer.
To
evaluate the therapeutic efficacy and safety profile of oxaliplatin, we reviewed patients who received oxaliplatin chemotherapy.
Methods:
We reviewed 48 patients who received combination chemotherapy with oxaliplatin, 5-FU, and leucovorin (LV) from Jan. 2000 to Dec. 2001. The combination chemotherapy consisted of oxaliplatin (85 §·/§³ on day 1) as a 2¡6 hour
infusion
followed by continuous infusion of 5-FU (1,500 §·/§³ on day 1, 2), concurrently with LV (45 §· on day 1, 2) as a 2 hour infusion. The combination chemotherapy interval was 2 weeks.
Results:
Of the 48 patients who received the combination chemotherapy with oxaliplatin, 5-FU, and LV, 25 cases were male, 23 cases were female. The median age was 51.4 years. The primary tumor sites were colon in 22 cases, and rectum in
26.
According to TNM stage at diagnosis, 1 case was stage ¥°, 5 cases were stage ¥±, 21 cases were stage ¥², and 21 cases were stage ¥³. The metastatic sites were liver in 29 cases, lung in 10, pelvis in 7, peritoneum in 5, bone in 1, lymph node in 1,
and
spleen in 2. Previous chemotherapy were Mayo regimen in 43 patients, irrinotecan in 1 patient. Four patients had not received previous chemotherapy. Previously of the 48 patients, we could assess the chemotherapy response for 25 cases. Complete
response
was not observed. Partial response was 3 cases (12%), stable disease in 12 cases (48%), progressive disease in 10 cases (40%). From 227 cycles analyzed, the main toxicity was gastrointestinal one. Peripheral neuropathy was identifed in 5
cases.
Conculsions:
We reviewed 48 patients with advanced colorectal cancer who received combination chemotherapy with oxaliplatin, 5-FU and LV. Of the 25 evaluable patients, the objective response rate was 12%. In our study, the combination
chemotherapy with oxaliplatin, 5-FU, LV has not resulted in improved response rate, but overall toxicity was acceptable.
Á¦ ¸ñ
ÁøÇ༺ ´ëÀåÁ÷Àå¾Ï¿¡¼ Oxaliplatin, 5-Fluorouracil, LeucovorinÀ» º´¿ëÇÑ ÈÇпä¹ýÀÇ ÀÓ»óÀû Àû¿ë: 48¿¹
Àú ÀÚ
À̽ÂÇö, ¾Èº´±Ç, ¹é½Â¾ð
¼Ò ¼Ó
À̽ÂÇö/°í½Å´ëÇб³ ÀÇ°ú´ëÇÐ º¹À½º´¿ø ¿Ü°úÇб³½Ç , ¾Èº´±Ç/, ¹é½Â¾ð/
ÃâÆÇÁ¤º¸
´ëÇÑ´ëÀåÇ×¹®ÇÐȸÁö 2002 | 18±Ç 6È£ 402 ~ 407, 6 pages
Å°¿öµå
´ëÀåÁ÷Àå¾Ï; Ç×¾ÏÈÇпä¹ý; ¿Á»ì¸®Çöóƾ; Colorectal cancer; Chemotherapy; Oxaliplatin;