대한대장항문학회

<b>Purpose:</b> The aim of this study is to confirm the association of human papillomavirus with colorectal cancer. <b>Methods:</b> We studied 44 patients who were received operation for colorectal cancer from 1, Jan. 1997 to 31, Dec. at Korea<br>University Guro Hospital. We used paraffinembedded tissue sections of colorectal adenocarcinomas and human cervical cell lines as a positive control. We also studied 10 cases of anal canal squamous cell carcinomas. The extracted DNA were analyzed<br>by<br>polymerase chain reaction and enzyme restriction method. <b>Results:</b> Human papillomavirus DNA was not detected in all specimen of colorectal adenocarcinomas. But in 3 of 10 (30%) of anal canal squamous carcinomas, human papillomavirus DNA was<br>detected. We identified this human papillomvirus DNA as type 16 by enzyme restriction technique. <b>Conclusions:</b> Human papillomavirus usually associated with malignant transformation are present in anal canal squamous cell carcinomas. This<br>study<br>also showed same result. But this association was absent from adenocarcinoma of the colon and rectum.<br>