대한대장항문학회

Metastases to the liver from carcinoma of the colon and rectum occur as many as 80% of<br>cases. As resection of metastases is proven to enhance survival and to reduce hepatic<br>recurrence, the criteria for selection of patients and surgery type appear to be indispensable.<br>Purpose: The aim of this study was to assess the prognostic factors after hepatic resection<br>for metastatic colorectal cancer and propose the optimal surgical principles for resection of<br>metastatic colorectal cancer.<br>Methods: Sixty-three patients who underwent initial hepatic resection for liver metastases<br>from colorectal cancer between 1989 and 1998 were analyzed regarding clinical and pathologic<br>parameters.<br>Results: Overall 5-year survival rate was 32%. Preoperative serum CEA level and resection<br>margin of metastatic tumors were found to be significant predictors for poor long-term<br>outcome. Resection margin of greater than 5 mm was closely associated with better survival.<br>In multivariate analysis, resection margin alone was an independent prognostic factor.<br>Conclusions: Preoperative serum CEA level and surgical resection margin may affect the<br>outcome for the patients who underwent hepatic resection for metastatic colorectal cancer.<br>Surgical resection margin must be kept enough to avoid re-recurrence or metastasis during<br>hepatic resection for metastatic colorectal cancer.<br>