대한대장항문학회

The liver is the predominant metastatic site of colorectal cancer. When the patients<br>general condition, the absence of extrahepatic metastases, number and locations of hepatic<br>lesions permit, hepatic resection may be curative and should be considered standard<br>therapy. Regional approaches, such as cryotherapy, alcohol injection, radiation therapy,<br>interstitial laser therapy, and chemoembolization even that may bring about effective<br>palliation suggest experimental approaches to the treatment of hepatic metastases.<br>Regional infusion of chemotherapeutic agent via hepatic artery has shown a great tumor<br>response, but further studies are needed for evaluation of precise benefit of this approach.<br>Manipulation of the gene level was recently possible and addressed for the treatment of<br>unresectable hepatic metastases, but still many problems to overcome are remained for the<br>effective delivery and selective expression of the therapeutic gene or gene product to the<br>target cells. Thus, new approaches to the colorectal cancer liver metastases are clearly<br>warranted.<br>