대한대장항문학회

Purpose: The DNA flow cytometric analysis in colorectal cancer has been studied for<br>more 10 years as an independent prognostic factor or a factor correlated with other<br>preexistent prognostic factors, such as the depth of invasion, lymph node status,<br>histologic differentiation, etc. To clarify the influence of DNA contents (DNA ploidy,<br>DNA index) and lymph node status on disease free survival in colorectal cancer, we<br>investigated the relationship between them, retrospectively. Methods : This study<br>included 198 patients with curatively resected Dukes'stage A, B, and C colorectal<br>cancer who had taken DNA flow cytometric analysis from June of 1996 to March of<br>1999 at Department of Surgery, Inha University Hospital. Results : In over all<br>twelve-month disease free survival, there were 92.5% in DNA diploid and 74.3% in<br>DNA aneuploid tumors. And so forth, there were 78.0% in positive and 91.9% in<br>negative lymph node tumors. in the event of a DNA index greater and lesser than 1.15,<br>the twelve-month disease free survival was 72.9% and 92.7%, respectively. These<br>results were statistically significant (p<0.05). Therefore, patients with a negative lymph<br>node, aneuploid one or DNA index greater than 1.15 had a longer disease free survival<br>than those with a positive lymph node, aneuploid one or DNA index greater than 1.15.<br>Conclusion : In conclusion, there seems to a significant relationship between DNA<br>contents and lymph node status on disease free survival. Thus, these factors are<br>considered to be value in predicting the recurrence of colorectal cancer.<br>