대한대장항문학회

Amyloidosis is known as a disease caused by the deposition of a insoluble and fibrous<br>amyloid protein in the extracellular space of various organs and tissue. Intestinal amyloid<br>deposition may develop motility disturbance, malabsorption, bleeding and perforation. A<br>70-year old woman with lower abdominal pain, watery diarrhea was admitted and had the<br>past history of diabetes mellitus, hypertension for 8 years and rheumatoid arthritis for 10 year.<br>On colonoscopic examination for evaluation of diarrhea, multiple edematous and shallow ulcers<br>was found from distal sigmoid to terminal ileum. A green colored positive birifringent stained<br>amorphous material was found in polarizing microscopy of colon biopsy specimen stained with<br>Congo-red on microscopic examination,. We report a case of amyloidosis causing colon ulcers<br>confirmed by colonoscopic biopsy with review literature.<br>