대한대장항문학회

Desmoid tumor is a subtype of fibromatosis arising from deep fascial or soft tissue<br>structure. It is characterized by locally aggressive behavior with a tendency to local<br>recurrence, but is generally accepted the lack of ability for distant metastasis. Although<br>excision is the best initial therapy, surgery is not always amenable in cases of lesions lying<br>in difficult anatomical area. Two female patients with recurrent desmoid tumor in abdomen<br>and pelvis after excision were treated with tamoxifen, goserelin, and sulindac. This therapy<br>led to a progressive decrease of tumor size within 13 months in one patient. However, in the<br>other patient, this combined therapy failed to reduce the size of the tumor. Despite the<br>success of combined therapy with hormone and nonsteroidal anti-inflammatory drug is<br>anecdotal, this treatment may improve the survival and reduce the recurrence in certain<br>sub-group of desmoid tumor.<br>