대한대장항문학회

Purpose : Growth patterns of colorectal carcinomas can be divided into polypoid growth<br>(PG) and nonpolypoid growth (NPG). This study was intended to find characteristic clinic<br>opathologic features and the expression status of p53, p21, and p16 with relation to growth<br>patterns in colorectal carcinomas. Methods : Sixty-one surgically resected colorectal carci<br>nomas including 43 PG and 18 NPG carcinomas were reviewed in this study. Immuno<br>histochemical stains for p53, p21, and p16 were done, and the results were analyzed with<br>respect to growth patterns, and other prognosic parameters. Results : PG carcinomas were<br>significantly correlated with adenoma (p=0.0001), and with favorable histology group (p=0.04).<br>On the contrary, NPG carcinomas were significantly correlated with unfavorable histology<br>group (p=0.04). In NPG carcinomas, the frequency of positive expression of p53 was higher<br>and the expression of p16 was lower than that of PG carcinomas. But there was no statistical<br>significance (p=0.150, 0.210 respectively). The expression of p21 has no difference between<br>NPG and PG carcinomas (p=0.953). Conclusions : As a result, it can be thought that the<br>tendency of higher expression of p53 and lower expression of p16 in NPG carcinomas than in<br>PG carcinomas may suggest more aggressive biologic behavior of NPG carcinomas.<br>