대한대장항문학회

The clinical value of the pre-(165 pts) and post-operative(149 pts) serum levels of<br>carcinoembryogenic antigen(CEA) in 190 patients(pts) with colorectal cancer was<br>investigated, who had a curative surgery and an abnormally elevated levels of CEA (><br>or=5 ng/ml) at Department of General Surgery, Chonbuk National University Hospital<br>during 1989 to 1996.<br>The results are as follows:<br>1) The preoperative positive rates of CEA level were 49(29.7%) of 165 patients, so<br>preoperative CEA level measurement was no usefulness for screening test of colorectal<br>cancer. The incidence of preoperatively elevated CEA levels in Dukes stages A, B, C,<br>and D were 0, 28.6, 32.8 and 42.9% respectively, There was significant association<br>between increased proportion of patients with preopertive serum CEA(≥ 5 ng/ml) and<br>the progressive stages of colorectal cancers(P<0.05).<br>2) There was no significant association between the frequency of abnormal CEA level<br>and histologic differentiation of tumor.<br>3) The recurrence rate was 16.4% and 30.6% in patients with preoperative CEA < 5<br>ng/ml and ≥5 ng/ml, respectively(p<0.05).<br>4) In patients with recurrence, the lymph node positive group(70.6%) was larger than<br>the negative(29.4%)(p<0.05), and preoperative positive rate of CEA value was 44% .<br>5) The recurrence rate in Dukes stages A, Bl, B2, Cl, C2, and D were 0, 8.7, 12.7,<br>16.7, 32.3, and 90.0% respectively(p<0.01).<br>6) There was no significant association between the frequency of abnormal CEA level<br>and location of tumor.<br>7) The recurrence rate was 12.3% and 65.7% in patients with postoperative CEA < 5<br>ng/ml and ≥ 5 ng/ml, respectively(p<0.01).<br>8) In patients with metastasis, postoperative positive rate of CEA level was 63%(p<<br>0.01).<br>