대한대장항문학회

Anal cancer is a relatively rare disease to supply consistent therapeutic modality. We<br>analysed 18 anal cancer patients treated from 1989 to 1996 at the Department of<br>Surgery, Asan Medical Center, to evaluate two categories of the treatment e.g. initial<br>surgery followed by radiochemotherapy and radiochemotherapy Preceding surgery. The<br>aim of this study is to evaluate the advantage and pitfall of both therapeutic options.<br>Among 18 patients presenting with carcinoma of the anus, the dominant histologic type<br>was squamous followed by cloacogenic and verrucous carcinoma, 72%, 17%,<br>11%<br>respectively According to the staging system of AJCC/UICC, T1 and T2 were 12<br>patients, NO were 7 patients. According to the treatment options, abdominoperineal<br>resection preceding radiochemotherapy were performed in 8 patients, Whereas surgery<br>after radiochemo-therapy were in 10 patients. Among the 8 patient with prior surgery,<br>two patients developed recurrent disease and one patient was dead. Among the 10<br>patient with prior radiochemotherapy, two patients developed recurrent disease and two<br>patients were dead. Histological differentiation of squamous cell carcinoma was<br>significantly related with survival. The metachronous lymph nodes metastasis showed<br>poorer prognosis than the synchronous metastasis. Radiochemotherapy shoud be<br>considered as primary therapy of anal cancer that obviated wide excision sacrificing<br>anorectal function.<br>