대한대장항문학회

The effect of perioperative blood transfusion on the survival rate of patients<br>of<br>colorectal cancer was studied. From January 1990 to December 1995, 533 patients with<br>colorectal cancer underwent surgical treatment in the department of surgery, Kangbuk<br>Samsung Medical Center. In these patients, 430 patients with Dukes stages A, B, and C<br>carcinoma were divided into two groups: those who received perioperative blood<br>transfusion and those who did not. Overall survival curves were constructed using<br>Kaplan-Meier method and the differences between curves were tested by using the<br>log-rank test. Comparison of variables between the transfused and nontransfused groups<br>were evaluated with the Student t test and Chi-square test with SPSS program. Two<br>hundred and three patients (47.2%) received transfusions within the perioperative period.<br>The transfused group included patients with tumors of more advanced stage such as<br>Dukes C(60.1% vs. 44.5%, p< 0.05) and more rectal cancer(88.2% vs. 55.5%, p < 0.05).<br>In the other variables such as age distribution, sex difference, histologic grade and<br>perioperative hemoglobin level, there was no significant difference between the<br>transfused and non-transfused group. Although the 5-year overall survival rate was<br>significantly lower in the transfused group than non-transfused(61% vs. 74.2%, p <<br>0.05), subgroup analysis according to the tumor location and Dukes stage showed no<br>statiscally significant difference in survival in each location and stage between the two<br>groups. It is postulated that the possible adverse influence of blood transfusion on the<br>survival of patients with colorectal cancer is linked to other prognostic features rather<br>than to the immunologic sequelae of the transfusion itself.<br>