대한대장항문학회

Background : Polyethylene glycol(PEG) has been the most widely used colonic lavage<br>solution. But large volume and salty taste of PEG solution is a problem which can lead<br>to the noncompliance and the poor bowel cleansing. Recent reports have suggested that<br>sodium phosphate solution of much smaller volume is more effective in colon cleansing<br>ability and more easier to complete. Therefore, this study was designed to compare two<br>solutions for colonoscopy and to determine the differences in either patient compliance or<br>cleansing ability.<br>Method : Eighty-two patients were randomized to take either oral sodium phosphate<br>solution or 2 liter of PEG solution. Patient's discomfort and tolerance during ingestion<br>was asessed by questionnaire and one colonoscopist who did not know the type of<br>solution, assessed colonic preparation status.<br>Results : Among 25 patients experiencing two separate colonoscopies with PEG<br>solution and sodium phosphate solution respectively, 19(76%) patients preferred sodium<br>phosphate solution. Sodium phosphate solution was found to be easier to take. Sodium<br>phosphate caused thirst more frequently(p=0.013) than PEG solution. Particulate stool and<br>water retention status were similar in two groups. Gas bubble formation that disturbs<br>luminal observation was more frequently found in sodium phosphate preparation<br>group(P=0.00). Sodium phosphate was more effective in right colon cleansing ability than<br>PEG preparation(P=0.04). The Colonoscopist assessed sodium phosphate as "good" in<br>47.2% vs 58.6% after PEG preparation as a whole, but there was no statistical<br>difference.<br>Conclusion : Sodium Phosphate solution is better tolerated and more easier to take<br>than PEG solution. Gas bubble formation is a correctable problem, but right colonic<br>cleansing effect is not. Our results showed that sodium phosphate is likely to be more<br>effective in colonic cleansing effect comparing to polyethylene glycol solution.<br>