대한대장항문학회

Gene expression of the nm23 and CD44 has been investigated in number of tumors, in<br>cluding colorectal cancer, breast cancer, and hepatocellular carcinoma. This study was<br>conducted to clarify the association between nm23 and CD44 protein expression and<br>metastatic potential in human colorectal cancer. To elucidate the role of the nm23 and<br>CD44 in human colorectal cancer, sections of formalin-fixed, paraffin-embeded tissue<br>from 59 primary colorectal cancer were stained immunohistochemically against nm23 and<br>CD44 proteins. Expression of the nm23 protein is not significantly correlate with<br>Dukes'stage and recurrence. However, the expression of the CD44 protein is significantly<br>higher in Dukes stage C as comparing with stage B.<br>