대한대장항문학회

In colon adenocarcinoma, it has been well known that the prognosis of the disease<br>depends on the Duke classification, histologic grade and serum CEA level.<br>To evaluate the relationship between conventional method(cellular differentiation by<br>histologic grade), argyrophilic method(Ag-NORs) and attractive method01ow cytometry),<br>we studied 30 cases of colon carcinoma who were operated at Department of Surgery,<br>Korea University Hospital, from Mar. 1987 to Feb. 1992.<br>The results were as follows :<br>1) Of the 30 cases of adenocarcinoma,21 cases(40%) were DNA aneuploid type.<br>Diploid type was 83.3% in well differentiate type, 57.2% in moderate differentiate type<br>and 33.3% in poorly differentiate type. There was a positive correlation between type of<br>ploidy and cellular differentiations of colon adenocarcinoma(r=0.28).<br>2) The cytometric S-phase had a significant difference with cellular differentiations of<br>colon adenocarcinoma(P=0.05) and cytometric GO/Gl phase and proliferation index had a<br>correlation with cellular differentiations of colon adenocarcinoma(r=-0.33, r=0.34).<br>3) In Ag-NORs study, the mean number of Ag-NORs was 5.68?.77 in aneuploid<br>type and 3.52?.75 in diploid type. The mean number of Ag-NORs had a significant<br>difference between dipoid types and aneuploid types(P=0.05).<br>4) There was a weak correlation between mean number of Ag-NORs and cytometric<br>G0/Gl phase,5-phase and proliferation index(r= -0.28, r=0.26, r=0.28).<br>5) The cytometric S-phase was 8.5?.0% in diploid type and 19.9?11.7% in<br>aneuploid type, Gl/Gl Phase was 86.7:k9.8% in diploid type and 75.6:In 11.5% in<br>aneuploid type, Proliferation index was 13.3:k9.8% in diploid type and 24.41k 11.5% in<br>aneuploid type. The cytometric S phase, G0/G1 phase and proliferation index had a<br>significant difference with ploidy pattern (P=0.006, 0.006, 0.007).<br>