대한대장항문학회

Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to rat<br>colon was investigated using the appearance of colonic Aberrant Crypt(AC),<br>a<br>preneoplastic lesion, as a marker. The number of AC foci per colon at experimental<br>week 4 was 2.5?.9; No ACs were observed in rats of the control group. A repeat<br>experiment showed that induction of AC foci by PhIP administration was reproducible<br>and a significant increase in the number of AC foci, 4.40?.14, was observed after 12<br>weeks of PhIP administration. The majority of ACs induced by PhIP were localized in<br>rectum. The minority were localized in the middle Part of the colon. These data<br>suggested that PhIP is possibly carcinogenic to rat colon.<br>