대한대장항문학회

41명의 복회음 절제술을 받은 환자를 대상으로 Taurolin의 복부관주의 임상적 효과에 대<br>하여 연구하였다. 그 결과 창상 감염으로 Taurolin을 사용한 군에서 5%, 사용 안한 군에서<br>는 14%의 감염율을 보였지만 통계학적으로는 차이가 없었다. 그러나 배액관을 통한 세균<br>배양에서는 Taurolin을 사용한 군에서 20예중 5예(25%)에서, 사용하지 않은 군에서는 21예<br>중 11예(52%)에서 장내 세균이 배양되어서 Taurolin을 사용한 군에서 유의하게 장내 세균<br>의 배양율을 낮았다. 따라서 창상감염이 호발하는 복회음 절제술에서 Taurolin의 관주요법<br>은 창상감염 및 이것에 의한 유병율을 줄이는데 기여하리라 기대된다<br>#초록#<br>Taurolin is a new chemotherapeutic agent, a derivative of endogenous amino-sulphonic<br>acid, taurine. Taurolin apparently acts on the micro-organisms by the transfer of<br>methylol molecules to the wall of the bacteria, causing their destruction and, at the<br>same time, denaturing the peptide-oligosaccharides and the lido-polysaccharides that<br>constitute the Gram-negative bacterial endotoxins. It may be administered at an<br>appropriate concentration by the intraperitoneal rout without toxic effect.<br>The aim of this study is to examine the effect of Taurolin irrigation in<br>abdominoperineal resection. From June 1991 to February 1992, 41 patients who<br>underwent abdominoperineal resection for rectal cancer entered the trial. Two percents of<br>Taurolin was instilled into the Pelvic cavity prior to closure of abdomen after saline<br>irrigation in 20 patients. Only saline was instilled in 21 patients. Complete blood count<br>and liver function study were checked Preoperatively and postoperative 7th<br>day.<br>Abdominal and Perineal wounds were closely examined postoperatively and the fluid<br>from Hemo-vac catheter was cultured.<br>There were no differences in complete blood count and liver function study.<br>The wound infection was found in one out of 20 patients(5% ) in Taurolin instilled<br>group and three out of 21 patients(14%) in saline instilled group. It was not statistically<br>different. In saline instilled group, the enteric bacteria were cultured in 11 out of 21<br>Patients(52%) and in Taurolin instilled group, 5 out of 20 patients(25% ). So culture rate<br>was significantly lower in Taurolin instilled group.<br>Although we could not find any statistically significant difference in wound<br>complication in this small number of patients, the culture rate of the enteric bacteria<br>decreased in Taurolin instilled group and 5% of wound infection rate in Taurolin<br>instilled group is relatively low infection rate in abdominoperineal resection as compared<br>to other reports.<br>