대한대장항문학회

Because approximately 5 to 6 percent of total colorectal cancer burden is accounted<br>for by hereditary nonpolyposis colorectal cancer(HNPCC), the genetic factor is the most<br>important risk in colorectal cancer. We have established the Korean<br>Hereditary<br>Colorectal Cancer Registry in June 1991 for early diagnosis and prevention of colorectal<br>cancer. Beacuse HNPCC is diagnosed only by family history, minimum criteria of<br>HNPCC was used in this study. The criteria is that 1) at least three relatives should<br>have histologically verified colorectal cancer; one of them should be a first degree<br>relative to the other two, familial adenomatous polyposis should be excluded, 2) at least<br>two successive generations should be affected, 3) in one of the relatives<br>colorectal<br>cancer should be diagnosed under 50 years of age.<br>In order to register the Patient of HNPCC, the medical records of 901 colorectal cancer<br>patients operated in SNUH from 1985 to 1990 were reviewed but no HNPCC was<br>identified. And then of 311 colorectal cancer patients from 1990 to 1991, 195 patients<br>were interviewed about the family history of cancer. Five HNPCC families were<br>identified: SNU-H1, SNU-H2, SNU-H3, SNU-H4, SNU-H5. The five families had 19<br>colorectal cancer patients(15 male, 4 female). Due to two metachronous Patients and one<br>synchronous Patient, total numbers of colorectal cancer site were 22; right side colon 4,<br>left side colon 10, unknown site 8. The average a9e at diagnosis was 47.6(range 25-73).<br>