대한대장항문학회

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Title		The Carcinogenic Effect with the Instillation of N-methyl-N-nitro-N-nitrosoguanidine in Sprague-Dawley Rats in the Colon and Rectum

Author		Bong Hwa Lee, Hyoung Duk Kim, Hong Moo Kim, Se Ho Kim, Jung Il Suh, Ze Hong Woo

Place of duty

Publicationinfo		Journal of Korean Soc Coloproctol 1992 \| Vol.8 No.1 \| 1 ~ 8, 8 pages

Keyword		Carcinogenesis; Indomethacin; Metronidazole;

Abstract		Large bowel carcinomas were induced with the instillation of N-methyl-N-nitro-N-<br>nitrosoguanidine(MNNG) in Spargure-Dawley rats. Histologic examinations showed that<br>malignant tumors such as adenocarcinoma, angiosarcoma, malignant lymphoma were<br>developed and, that mucosal chanties such as ischemic chanties, submucosal lymphoid<br>infiltration were notified and, that reactive lymphoid hyperplasia with plasma cell<br>dominance and with occasional abscesses. There were no significant difference in the<br>incidence of histopathology among the groups treated with MNNG only, MNNG and<br>indomethacin, MNNG and metronidazole MNNG and both. But there was no malignant<br>tumors in the group treated with MNNG and indomethacin.<br>

제 목		N-methyl-N-nitro-N-nitrosoguanidine의 직장주입에 의한 Sprague-Dawley 쥐에서의 발암효과

저 자		이봉화, 김형덕, 김홍무, 김세호, 우제홍, 서정일

소 속		이봉화/국립의료원 일반외과, 김형덕/국립의료원 일반외과, 김홍무/국립의료원 일반외과, 김세호/국립의료원 일반외과, 우제홍/국립의료원 일반외과, 서정일/국립의료원 병리과

출판정보		대한대장항문학회지 1992 \| 8권 1호 1 ~ 8, 8 pages

키워드		Carcinogenesis; Indomethacin; Metronidazole;